SEVERE WX : High Wind Warning - Wind Advisory - Flash Flood Watch - Flood Watch View Alerts

FDA vaccine advisers recommend authorization of Johnson & Johnson's coronavirus vaccine

Vaccine advisers to the US Food and Drug Administration voted Friday to recommend the agency grant emergency use authorization to Johnson & Johnson's coronav...

Posted: Feb 26, 2021 2:35 PM

Vaccine advisers to the US Food and Drug Administration voted Friday to recommend the agency grant emergency use authorization to Johnson & Johnson's coronavirus vaccine.

The FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC) voted unanimously to recommend EUA of the vaccine in people 18 and older.

If the FDA acts on the recommendation -- and it's expected to do so quickly -- the vaccine will become the third authorized for use in the United States. It will be the first one-shot vaccine, and one that can be stored in regular refrigerators, making it easier to distribute than the Pfizer/BioNTech and Moderna vaccines, which are more delicate and require two doses.

The vaccine, made by Johnson & Johnson's vaccine arm, Janssen, was tested in advanced clinical trials in more than 44,000 people in the US, South Africa and Latin America. Globally, it showed an overall efficacy of 66% in preventing moderate-to-severe disease. In the US, this efficacy was 72% and it was 85% effective in preventing severe disease. No one who got the vaccine died of Covid-19 during the trial.

Top US health officials have said vaccination is the best way to bring the coronavirus pandemic under control. The virus has infected more than 28 million Americans and killed more than half a million.

"We urgently need more vaccines under EUA to protect the millions of Americans who remain at risk," Dr. Greg Poland, head of the Mayo Clinic's Vaccine Research Group, told the meeting.

"We need a vaccine that can be quickly mass produced," Poland told Friday's meeting. "We'd want to see a reasonable duration of efficacy and protection," he added. "The Janssen vaccine candidate checks nearly all the boxes."

How the vaccine works

Janssen's vaccine is different from the Pfizer and Moderna vaccines, which are made using a new technology that employs genetic material called messenger RNA or mRNA. Janssen's vaccine uses a common cold virus called adenovirus 26. It has been genetically engineered so that it cannot replicate in the body. Instead, it infects a few cells in the arm when injected, carrying the genetic code for a small part of the coronavirus. Those cells then produce material that looks like pieces of the virus to the immune system, stimulating an immune response.

It's an older vaccine technology. "The military has used adenovirus vaccines a lot," Dr. Arnold Monto, an epidemiologist at the University of Michigan's School of Public Health who chairs the VRBPAC, said during the meeting.

Although the Johnson & Johnson vaccine does not appear to have the astonishing 94% to 95% efficacy of the Pfizer and Moderna vaccines, researchers told the VRBPAC committee that it was tested at a different time -- when more virus was circulating and after new variants had arisen that have the ability to evade some of the immune response. Although they were not able to show that these variants were responsible for the apparent lower efficacy of Johnson & Johnson's vaccine, they told the committee it could have been a factor.

What happens next

If the FDA issues an EUA, it could come as soon as Friday night. It's up to the US Centers for Disease Control and Prevention to decide whether the vaccine should actually be given to Americans. The CDC's Advisory Committee on Immunization Practices (ACIP) has scheduled a meeting for Sunday to take up the question. ACIP will vote on Sunday afternoon on whether the CDC should OK the vaccine's distribution and may also designate priority groups.

The CDC director, Dr. Rochelle Walensky, will then give the final go-ahead.

The US federal government says it's ready to distribute about 4 million doses of the vaccine immediately.

Dr. Anthony Fauci, the chief medical adviser to the White House and director of the National Institute of Allergy and Infectious Diseases, has said Americans should not try to pick and choose vaccines but rather, get whichever vaccine is available.

Oregon Coronavirus Cases

Data is updated nightly.

Cases: 357526

Reported Deaths: 4284
CountyCasesDeaths
Multnomah55810707
Washington38782324
Marion36837455
Clackamas29779309
Lane27744302
Jackson23059310
Deschutes20336125
Umatilla14492150
Linn12911131
Douglas12118243
Josephine9384196
Yamhill8715113
Klamath8020119
Polk737381
Malheur563677
Benton549431
Coos503794
Columbia382644
Jefferson376052
Lincoln319939
Union319549
Crook291846
Wasco288841
Clatsop244328
Baker203529
Tillamook196932
Hood River192837
Morrow185023
Curry180625
Harney113927
Grant100013
Lake93912
Wallowa68612
Gilliam1544
Sherman1523
Wheeler1121
Unassigned00

California Coronavirus Cases

Data is updated nightly.

Cases: 4850807

Reported Deaths: 71341
CountyCasesDeaths
Los Angeles148419226540
Riverside3716705041
San Diego3673614183
San Bernardino3586775692
Orange3242885562
Sacramento1596362309
Kern1463481648
Fresno1463182094
Santa Clara1455431897
Alameda1206921400
San Joaquin1027761721
Ventura1010381167
Contra Costa1000181008
Stanislaus862991335
Tulare80375978
San Francisco54440649
San Mateo54168623
Monterey50911586
Solano46063341
Santa Barbara45223523
Merced42422581
Sonoma40997404
Placer39435429
Imperial36071766
Kings32938325
San Luis Obispo29973333
Madera23955285
Shasta23924352
Butte23818273
Santa Cruz21034221
Yolo20397248
Marin17706244
El Dorado17207149
Sutter13937175
Napa12898100
Yuba1011582
Tehama9534110
Humboldt9269109
Nevada916790
Mendocino766787
Lassen754347
San Benito744972
Tuolumne691790
Lake6631105
Amador547364
Siskiyou451246
Glenn438433
Calaveras391481
Del Norte358742
Colusa307618
Inyo214241
Mono16723
Plumas16607
Mariposa133916
Trinity88011
Modoc6895
Sierra1880
Unassigned1460
Alpine1050
Out of CA00
Medford
Partly Cloudy
57° wxIcon
Hi: 57° Lo: 49°
Feels Like: 57°
Brookings
Cloudy
56° wxIcon
Hi: 55° Lo: 50°
Feels Like: 56°
Crater Lake
Cloudy
57° wxIcon
Hi: 35° Lo: 28°
Feels Like: 57°
Grants Pass
Cloudy
57° wxIcon
Hi: 56° Lo: 49°
Feels Like: 57°
Klamath Falls
Cloudy
48° wxIcon
Hi: 46° Lo: 40°
Feels Like: 43°
More rain expected overnight into Monday, winds starting to weaken
KDRV Radar
KDRV Fire Danger
KDRV Weather Cam

Community Events