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Lab studies suggest Pfizer, Moderna vaccines can protect against coronavirus variant

A new report published in the New England Journal of Medicine on Wednesday suggests that Pfizer-BioNTech's Covid-19 vaccine can protect people against concer...

Posted: Feb 18, 2021 12:24 AM

A new report published in the New England Journal of Medicine on Wednesday suggests that Pfizer-BioNTech's Covid-19 vaccine can protect people against concerning new coronavirus variants, including one first seen in South Africa called B.1.351.

For the study, researchers at Pfizer and the University of Texas Medical Branch genetically engineered versions of the virus to carry some of the mutations found in B.1.351. They tested them against blood samples taken from 15 people who had received two doses of the Pfizer/BioNTech vaccine as part of a clinical trial.

While the blood serum samples produced less neutralizing antibody activity, it was still enough to neutralize the virus, they wrote in a letter to the journal. This is in line with other studies. And it's well within what is seen with other viruses, one of the researchers said.

"Although we do not yet know exactly what level of neutralization is required for protection against COVID-19 disease or infection, our experience with other vaccines tells us that it is likely that the Pfizer vaccine offers relatively good protection against this new variant," Scott Weaver, director of the Institute for Human Infections and Immunity at the University of Texas Medical Branch and an author of the study, told CNN.

"The reduction in the levels of neutralization against the South African variant of about 2/3 is fairly small compared to variations in neutralization levels generated by vaccines against other viruses that have even more variability in their protein sequences than SARS-CoV-2," Weaver added.

Pfizer said there is no evidence in real life that the variant escapes the protection offered by its vaccine. "Nevertheless, Pfizer and BioNTech are taking the necessary steps, making the right investments, and engaging in the appropriate conversations with regulators to be in a position to develop and seek authorization for an updated mRNA vaccine or booster once a strain that significantly reduces the protection from the vaccine is identified," Pfizer said in a statement.

Separately, a team at the National Institutes of Health and Moderna published a letter in the same journal outlining findings from an experiment they reported last month. They also reported a reduction in the antibody response to viruses genetically engineered to look like the B.1.351 variant -- but not enough of a reduction to make the vaccine work any less effectively.

"Despite this reduction, neutralizing titer levels with (the variant discovered in South Africa) remain above levels that are expected to be protective," the company said in a statement.

They found no reduction in efficacy against a variant first seen in the UK and known as B.1.1.7.

Oregon Coronavirus Cases

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Cases: 207106

Reported Deaths: 2757
CountyCasesDeaths
Multnomah40396614
Washington26812249
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Jackson11549146
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Umatilla860987
Linn562281
Yamhill478679
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Polk400556
Douglas389583
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Harney4339
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Sherman701
Wheeler351
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Cases: 3810808

Reported Deaths: 63373
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Los Angeles124790924459
Riverside3017994627
San Bernardino2993204850
San Diego2818863771
Orange2731055113
Santa Clara1201922190
Kern1107991404
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San Joaquin748081440
Contra Costa70770813
Stanislaus635351070
Tulare49802849
Monterey43842432
San Mateo42685581
San Francisco37275556
Santa Barbara34621455
Solano33762266
Merced32315479
Sonoma30957317
Imperial28855741
Placer23604300
Kings23202247
San Luis Obispo21448261
Madera16647245
Santa Cruz16246208
Marin14208230
Yolo14165212
Butte12668195
Shasta12630233
El Dorado10401116
Napa1002880
Sutter9666113
Yuba651251
San Benito610963
Lassen579925
Tehama573563
Nevada493175
Humboldt450849
Mendocino434050
Tuolumne421671
Amador374247
Lake356345
Glenn243327
Siskiyou239837
Colusa228818
Calaveras220856
Del Norte14588
Inyo143438
Mono12984
Plumas7376
Modoc5635
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