STREAMING NOW: Watch Now

New treatment approved for drug-resistant tuberculosis

The US Food and Drug Administration approved a new treatment for highly drug-resistant tuberculosis, offering new hope in the fight against the world's...

Posted: Aug 16, 2019 3:29 AM
Updated: Aug 16, 2019 3:39 AM

The US Food and Drug Administration approved a new treatment for highly drug-resistant tuberculosis, offering new hope in the fight against the world's most deadly infectious disease.

TB most affects the lungs and can be particularly difficult to treat. Drug-resistant strains are on the increase due to incomplete and challenging courses of treatment that last for more than 18 months.

Pretomanid, a compound developed by the nonprofit TB Alliance and approved by the FDA on Wednesday, forms part of a three-drug regimen that people can take orally over six months. It treats two drug-resistant strains of the disease, XDR-TB and MDR-TB.

"Until very recently, people infected with highly drug-resistant TB had poor treatment options and a poor prognosis," said Dr. Francesca Conradie, principal investigator of the trial. "This new regimen provides hope with nine out of 10 patients achieving culture negative status at six months post-treatment with this short, all-oral regimen."

Tuberculosis claims 4,400 lives a day worldwide. According to the World Health Organization, highly drug-resistant strains account for more than 500,000 of the 10 million new cases of the disease each year and are found in 127 countries around the world.

Scientists tested safety and effectiveness of Pretomanid, which is taken together with bedaquiline -- approved as a TB treatment in 2012 -- and linezolid, an antibiotic, in patients in South Africa.

Of the 107 patients who were evaluated six months after the end of therapy, 95 (89%) had a successful outcome.

South Africa's burden of the airborne disease is particularly high, as a high incidence of HIV works with drug-resistant TB, weakening immune systems to make people more susceptible.

"The bacterium that causes tuberculosis can develop resistance to the antibiotics used to treat it. Multidrug-resistant TB and extensively drug-resistant TB are public health threats due to limited treatment options," FDA Principal Deputy Commissioner Amy Abernethy said in a statement.

Pretomanid is expected to be available in the United States by the end of this year, with the European Medicines Agency and the World Health Organization highly likely to follow suit and approve the treatment.

Pretomanid is only the third new anti-TB drug approved for use by the FDA in more than 40 years.

Treatment of highly drug-resistant TB has traditionally been complex and lengthy, with patients taking a combination of as many as eight antibiotics, some involving daily injections, for 18 months or longer. Some older regimens can cause patients to lose their hearing.

Dr. Mel Spigelman, president and CEO of TB Alliance, said the new "regimen will hopefully provide a shorter, more easily manageable and highly efficacious treatment for those in need."

"FDA approval of this treatment represents a victory for the people suffering from these highly drug-resistant forms of the world's deadliest infectious disease."

Oregon Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 44388

Reported Deaths: 675
CountyConfirmedDeaths
Multnomah9653167
Washington608278
Marion6068109
Umatilla346145
Clackamas330966
Lane250127
Malheur196738
Jackson18657
Deschutes120913
Yamhill102515
Linn86316
Polk67515
Jefferson60910
Morrow5547
Lincoln51913
Union4872
Benton4646
Klamath4313
Douglas3738
Wasco35216
Hood River2861
Columbia2751
Josephine2733
Coos2621
Clatsop2510
Baker1433
Crook1162
Tillamook750
Curry581
Wallowa512
Lake470
Harney370
Sherman220
Gilliam120
Grant120
Wheeler10
Unassigned00

California Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 928028

Reported Deaths: 17618
CountyConfirmedDeaths
Los Angeles3063277056
Riverside680501319
San Bernardino643671074
Orange597181475
San Diego56369888
Kern34154422
Fresno31321443
Sacramento26018500
Santa Clara24867406
Alameda23775463
San Joaquin21994492
Contra Costa18981246
Stanislaus17872401
Tulare17800292
Ventura14486166
Imperial13038338
San Francisco12320147
Monterey1161695
San Mateo11341161
Santa Barbara9919126
Sonoma9646136
Merced9623155
Kings850283
Solano763476
Marin7121127
Madera509476
Placer435359
San Luis Obispo426532
Yolo326660
Butte314353
Santa Cruz286125
Shasta204631
Napa200916
Sutter189712
San Benito146115
El Dorado13804
Yuba134610
Mendocino115621
Tehama9259
Lassen7721
Lake70417
Glenn6823
Nevada6358
Humboldt57110
Colusa5556
Calaveras34721
Amador33816
Tuolumne2886
Inyo24115
Siskiyou2210
Mono1822
Del Norte1811
Mariposa812
Plumas790
Modoc480
Trinity280
Alpine80
Sierra60
Unassigned00
Medford
Clear
44° wxIcon
Hi: 75° Lo: 41°
Feels Like: 44°
Brookings
Clear
48° wxIcon
Hi: 67° Lo: 50°
Feels Like: 48°
Crater Lake
Few Clouds
28° wxIcon
Hi: 64° Lo: 32°
Feels Like: 28°
Grants Pass
Scattered Clouds
39° wxIcon
Hi: 71° Lo: 38°
Feels Like: 39°
Klamath Falls
Few Clouds
28° wxIcon
Hi: 66° Lo: 28°
Feels Like: 28°
Sunny and pleasant Halloween
KDRV Radar
KDRV Fire Danger
KDRV Weather Cam

Community Events